705 research outputs found
Comments on alternative calculations of the broadening of spectral lines of neutral sodium by H-atom collisions
With the exception of the sodium D-lines recent calculations of line
broadening cross-sections for several multiplets of sodium by Leininger et al
(2000) are in substantial disagreement with cross-sections interpolated from
the tables of Anstee and O'Mara (1995) and Barklem and O'Mara (1997). The
discrepancy is as large as a factor of three for the 3p-4d multiplet. The two
theories are tested by using the results of each to synthesize lines in the
solar spectrum. It is found that generally the data from the theory of Anstee,
Barklem and O'Mara produce the best match to the observed solar spectrum. It is
found, using a simple model for reflection of the optical electron by the
potential barrier between the two atoms, that the reflection coefficient is too
large for avoided crossings with the upper states of subordinate lines to
contribute to line broadening, supporting the neglect of avoided ionic
crossings by Anstee, Barklem and O'Mara for these lines. The large
discrepancies between the two sets of calculations is a result of an
approximate treatment of avoided ionic crossings for these lines by Leininger
et al (2000).Comment: 18 pages, 5 ps figures included, to appear in J Phys B: At. Mol. Opt.
Phy
Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals,
there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death
receptors’ such as Fas/APO-1; and the ‘intrinsic’ pathway, which is triggered by diverse cellular stresses, and is regulated by prosurvival
and pro-apoptotic members of the Bcl-2 family of proteins. Pro-survival Mcl-1, which can block activation of the proapoptotic
proteins, Bax and Bak, appears critical for the survival and maintenance of multiple haemopoietic cell types. To
investigate the impact on haemopoiesis of simultaneously inhibiting both apoptosis pathways, we introduced the vavP-Mcl-1
transgene, which causes overexpression of Mcl-1 protein in all haemopoietic lineages, into Faslpr/lpr mice, which lack functional
Fas and are prone to autoimmunity. The combined mutations had a modest impact on myelopoiesis, primarily an increase in the
macrophage/monocyte population in Mcl-1tg/lpr mice compared with lpr or Mcl-1tg mice. The impact on lymphopoiesis was
striking, with a marked elevation in all major lymphoid subsets, including the non-conventional double-negative (DN) T cells
(TCRβ+
CD4–
CD8–
B220+
) characteristic of Faslpr/lpr mice. Of note, the onset of autoimmunity was markedly accelerated in Mcl-1tg/lpr
mice compared with lpr mice, and this was preceded by an increase in immunoglobulin (Ig)-producing cells and circulating
autoantibodies. This degree of impact was surprising, given the relatively mild phenotype conferred by the vavP-Mcl-1 transgene
by itself: a two- to threefold elevation of peripheral B and T cells, no significant increase in the non-conventional DN T-cell
population and no autoimmune disease. Comparison of the phenotype with that of other susceptible mice suggests that the
development of autoimmune disease in Mcl-1tg/lpr mice may be influenced not only by Ig-producing cells but also other
haemopoietic cell types
Automated analysis of free-text comments and dashboard representations in patient experience surveys: a multimethod co-design study
BACKGROUND: Patient experience surveys (PESs) often include informative free-text comments, but with no
way of systematically, efficiently and usefully analysing and reporting these. The National Cancer Patient
Experience Survey (CPES), used to model the approach reported here, generates > 70,000 free-text
comments annually. MAIN AIM: To improve the use and usefulness of PES free-text comments in driving health service changes that improve the patient experience. SECONDARY AIMS: (1) To structure CPES free-text comments using rule-based information retrieval (IR) (‘text
engineering’), drawing on health-care domain-specific gazetteers of terms, with in-built transferability to
other surveys and conditions; (2) to display the results usefully for health-care professionals, in a digital toolkit
dashboard display that drills down to the original free text; (3) to explore the usefulness of interdisciplinary
mixed stakeholder co-design and consensus-forming approaches in technology development, ensuring that
outputs have meaning for all; and (4) to explore the usefulness of Normalisation Process Theory (NPT) in
structuring outputs for implementation and sustainability. DESIGN: A scoping review, rapid review and surveys with stakeholders in health care (patients, carers,
health-care providers, commissioners, policy-makers and charities) explored clinical dashboard design/patient
experience themes. The findings informed the rules for the draft rule-based IR [developed using half of the
2013 Wales CPES (WCPES) data set] and prototype toolkit dashboards summarising PES data. These were
refined following mixed stakeholder, concept-mapping workshops and interviews, which were structured to
enable consensus-forming ‘co-design’ work. IR validation used the second half of the WCPES, with comparison
against its manual analysis; transferability was tested using further health-care data sets. A discrete choice
experiment (DCE) explored which toolkit features were preferred by health-care professionals, with a simple
cost–benefit analysis. Structured walk-throughs with NHS managers in Wessex, London and Leeds explored
usability and general implementation into practice. KEY OUTCOMES: A taxonomy of ranked PES themes, a checklist of key features recommended for digital
clinical toolkits, rule-based IR validation and transferability scores, usability, and goal-oriented, cost–benefit
and marketability results. The secondary outputs were a survey, scoping and rapid review findings, and
concordance and discordance between stakeholders and methods. RESULTS: (1) The surveys, rapid review and workshops showed that stakeholders differed in their
understandings of the patient experience and priorities for change, but that they reached consensus on
a shortlist of 19 themes; six were considered to be core; (2) the scoping review and one survey explored
the clinical toolkit design, emphasising that such toolkits should be quick and easy to use, and embedded
in workflows; the workshop discussions, the DCE and the walk-throughs confirmed this and foregrounded
other features to form the toolkit design checklist; and (3) the rule-based IR, developed using noun and
verb phrases and lookup gazetteers, was 86% accurate on the WCPES, but needs modification to improve
this and to be accurate with other data sets. The DCE and the walk-through suggest that the toolkit would
be well accepted, with a favourable cost–benefit ratio, if implemented into practice with appropriate
infrastructure support. LIMITATIONS: Small participant numbers and sampling bias across component studies. The scoping review
studies mostly used top-down approaches and focused on professional dashboards. The rapid review of
themes had limited scope, with no second reviewer. The IR needs further refinement, especially for
transferability. New governance restrictions further limit immediate use. CONCLUSIONS: Using a multidisciplinary, mixed stakeholder, use of co-design, proof of concept was shown
for an automated display of patient experience free-text comments in a way that could drive health-care
improvements in real time. The approach is easily modified for transferable application. FUTURE WORK: Further exploration is needed of implementation into practice, transferable uses and
technology development co-design approaches. FUNDING: The National Institute for Health Research Health Services and Delivery Research programme
On the influence of Stark broadening on Si I lines in stellar atmospheres
We study the influence of Stark broadening and stratification effects on Si\i
lines in the rapidly oscillating (roAp) star 10 Aql, where the Si\i 6142.48 \AA
and 6155.13 \AA lines are asymmetrical and shifted. First we have calculated
Stark broadening parameters using the semiclassical perturbation method for
three Si\i lines: 5950.2 \AA, 6142.48 \AA and 6155.13 \AA. We revised the
synthetic sp$ calculation code taking into account both Stark width and shift
for these lines. From the comparison of our calculations with the observations
we found that Stark broadening + the stratification effect can explain
asymmetry of the Si\i 6142.48 \AA and 6155.13 \AA lines in the atmospere of
roAp star 10 Aql.Comment: Accepted to A&
The membrane change in En(a-) human erythrocytes. Absence of the major erythrocyte sialoglycoprotein
Modified p-modes in penumbral filaments?
Aims: The primary objective of this study is to search for and identify wave
modes within a sunspot penumbra.
Methods: Infrared spectropolarimetric time series data are inverted using a
model comprising two atmospheric components in each spatial pixel. Fourier
phase difference analysis is performed on the line-of-sight velocities
retrieved from both components to determine time delays between the velocity
signals. In addition, the vertical separation between the signals in the two
components is calculated from the Stokes velocity response functions.
Results: The inversion yields two atmospheric components, one permeated by a
nearly horizontal magnetic field, the other with a less-inclined magnetic
field. Time delays between the oscillations in the two components in the
frequency range 2.5-4.5 mHz are combined with speeds of atmospheric wave modes
to determine wave travel distances. These are compared to expected path lengths
obtained from response functions of the observed spectral lines in the
different atmospheric components. Fast-mode (i.e., modified p-mode) waves
exhibit the best agreement with the observations when propagating toward the
sunspot at an angle ~50 degrees to the vertical.Comment: 8 pages, 12 figures, accepted for publication in Astronomy &
Astrophysic
Improved Laboratory Transition Probabilities for Neutral Chromium and Re-determination of the Chromium Abundance for the Sun and Three Stars
Branching fraction measurements from Fourier transform spectra in conjunction
with published radiative lifetimes are used to determine transition
probabilities for 263 lines of neutral chromium. These laboratory values are
employed to derive a new photospheric abundance for the Sun: log (Cr
I) = 5.640.01 (). These Cr I solar abundances do
not exhibit any trends with line strength nor with excitation energy and there
were no obvious indications of departures from LTE. In addition, oscillator
strengths for singly-ionized chromium recently reported by the FERRUM Project
are used to determine: log (Cr II) = 5.770.03 (). Transition probability data are also applied to the spectra of three
stars: HD 75732 (metal-rich dwarf), HD 140283 (metal-poor subgiant), and CS
22892-052 (metal-poor giant). In all of the selected stars, Cr I is found to be
underabundant with respect to Cr II. The possible causes for this abundance
discrepancy and apparent ionization imbalance are discussed.Comment: 44 pages, 6 figure
First-Digit Law in Nonextensive Statistics
Nonextensive statistics, characterized by a nonextensive parameter , is a
promising and practically useful generalization of the Boltzmann statistics to
describe power-law behaviors from physical and social observations. We here
explore the unevenness of the first digit distribution of nonextensive
statistics analytically and numerically. We find that the first-digit
distribution follows Benford's law and fluctuates slightly in a periodical
manner with respect to the logarithm of the temperature. The fluctuation
decreases when increases, and the result converges to Benford's law exactly
as approaches 2. The relevant regularities between nonextensive statistics
and Benford's law are also presented and discussed.Comment: 11 pages, 3 figures, published in Phys. Rev.
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